Analysis of the correlation between serum syndecan-1 and peptidylarginine deiminase 2 levels and short-term poor prognosis in patients with sepsis

Zhu Mengmeng; Zhou Shusheng

doi:10.3760/j.issn.1673-4777.2025.10.016

Abstract：Objective To investigate the correlation between serum syndecan-1(SDC-1)and peptidy-larginine deiminase 2(PAD2)levels and short-term poor prognosis in patients with sepsis.Methods A total of 150 patients with sepsis admitted to Anhui Provincial Hospital from January 2022 to December 2024 were selected as the observation group,and 150 healthy people in the same period were selected as the control group.The serum levels of SDC-1 and PAD2 were compared between the two groups.The patients with sepsis were divided into poor prognosis group and good prognosis group according to the 28 d survival.The correlation between serum SDC-1,PAD2 and the risk of short-term poor prognosis in patients with sepsis was analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of related indicators for short-term poor prognosis in patients with sepsis.Results The serum levels of SDC-1 and PAD2 in the observation group were higher than those in the control group[(240±50)μg/L vs(126±26)μg/L,(39±15)μg/L vs(10±4)μg/L](both P＜0.001).Among 150 patients with sepsis,46 patients(30.7％)died within 28 d and were classified into the poor prognosis group,and the remaining 104 patients were classified into the good prognosis group.The serum levels of SDC-1 and PAD2 in the poor prognosis group were higher than those in the good prognosis group[(274±46)μg/L vs(225±40)μg/L,(49±18)μg/L vs(35±12)μg/L](both P＜0.001).Restricted cubic spline analysis showed that the correlation strength between serum SDC-1 and PAD2 levels and the risk of short-term poor prognosis in patients with sepsis showed an approximate J-type non-linear dose-response relationship.Thiex2 Phi coefficient correlation and binomial correlation test showed that serum SDC-1 and PAD2 levels were positively correlated with the risk of short-term poor prognosis in patients with sepsis(all P＜0.001).ROC curve analysis showed that the area under the curve of SDC-1 and PAD2 in predicting the risk of short-term poor prognosis in patients with sepsis was 0.858 and 0.760,respectively.Conclusion The levels of serum SDC-1 and PAD2 in patients with sepsis are abnormally increased,and both of them are positively correlated with short-term poor prognosis of patients,which can be used to predict short-term poor prognosis of such patients.