The predictive value of thyroid hormone sensitivity indicators for postoperative recurrence and metastasis of differentiated thyroid cancer in the elderly
Wang Ping
Yao Wenjuan
Wang Dan
Shi Liying
Abstract：Objective To explore the predictive value of thyroid hormone sensitivity indicators for postop-erative recurrence and metastasis of differentiated thyroid cancer(DTC)in the elderly.Methods A total of 106 elderly patients with DTC after surgery admitted to Peking University First Hospital Taiyuan Hospital from June 2019 to April 2020 were retrospectively selected.The patients were divided into recurrence and metastasis group(observation group,19 cases)and non-recurrence and metastasis group(control group,87 cases)according to whether recurrence and metastasis occurred 3 years after operation.Logistic regression model was used to analyze the influencing factors,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of thyroid hormone sensitivity indicators for postoperative recurrence and metastasis in elderly DTC patients.Results There were significant differences in TNM staging,postoperative 131I treatment,surgical methods,the proportion of postoperative thyroid-stimulating hormone(TSH)therapy,the levels of free triiodothyronine,TSH,thyroid stimulating hormone index(TSHI),thyroid-stimulating hormone resistance index(TT4RI),and thyroid feedback Quantile-based index(TFQI)between the two groups(all P＜0.05).Binary Logistic regression analysis showed that stage Ⅲ-Ⅳ,TSH,TSHI,TT4RI,TFQI,postoperative 131I treatment,total thyroidectomy,and no postoperative TSH therapy were risk factors for postoperative recurrence and metastasis in elderly DTC patients(all P＜0.05).ROC curve analysis showed that the area under the curve of thyroid hormone sensitivity indicators TSHI,TT4RI and TFQI combined to predict postoperative recurrence and metastasis of DTC patients was 0.977(95％confidence interval:0.937-0.999).Conclusions The combination of thyroid hormone sensitivity indicators TSHI,TT4RI and TFQI has high accuracy and predictive value in predicting postoperative recurrence and metastasis in elderly DTC patients,which can be used as effective indicators for clinical prediction of postoperative recurrence and metastasis in elderly DTC patients.
Keywords：Differentiated thyroid cancerThyroid hormone sensitivity indicatorsRecurrenceMetastasis
Publication Date：2025-10-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1494-1498 )