Association between nocturnal systolic blood pressure and estimated glomerular filtration rate in hypertensive patients with heart failure with preserved ejection fraction
Shi Futian
Li Jiaxin
Su Quanbin
Yu Jing
Abstract：Objective To investigate the association between nocturnal systolic blood pressure(nSBP)and estimated glomerular filtration rate(eGFR)in hypertensive patients with heart failure with preserved ejection fraction(HFpEF).Methods A total of 305 hypertensive patients with HFpEF in the Second Hospital,Lanzhou University from December 1,2017 to June 30,2024 were retrospectively selected.According to nSBP,the patients were divided into high-nSBP group(222 cases),middle-nSBP group(69 cases),and low-nSBP group(14 cases).The clinical data of the three groups were compared,Pearson or Spearman model was used for correlation analysis,and multivariate linear regression was used to analyze the independent risk factors affecting eGFR.Results Systolic blood pressure and diastolic blood pressure in the low-nSBP group and the middle-nSBP group were lower than those in the high-nSBP group at each time point,and nSBP in the low-nSBP group was lower than that in the middle-nSBP group(all P＜0.05).The level of serum creatinine in the middle-nSBP group was lower than that in the high-nSBP group and low-nSBP group,and the level of eGFR was higher than that in the high-nSBP group and low-nSBP group(all P＜0.05).eGFR was negatively correlated with age,serum uric acid and serum creatinine(r=-0.247,-0.205,-0.606,all P＜0.05),and positively correlated with body mass index,heart rate and daytime diastolic blood pressure in hypertensive patients with HFpEF(r=0.179,0.173,0.116,all P＜0.05).Age,serum creatinine,the ratio of mitral E velocity to early diastolic mitral annular velocity,and nSBP were independent risk factors for eGFR(all P＜0.05).Conclusion In patients with hypertension and HFpEF,either high or low nSBP will lead to a decrease in eGFR.
Keywords：HypertensionHeart failure with preserved ejection fractionNocturnal systolic blood pressureEstimation glomerular filtration rate
Publication Date：2025-10-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1465-1469 )