Study on the predictive value of serum long non-coding RNA expression in patients with acute myocardial infarction for coronary no-reflow during percutaneous coronary intervention
Dong Qing
Wang Xuexiang
Xu Li
Abstract：Objective To investigate the predictive value of serum long non-coding RNA(lncRNA)HOX transcript antisense RNA(HOTAIR)and small nucleolar RNA host gene 16(SNHG16)expression on coronary no-reflow(CNR)during percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 80 AMI patients who underwent PCI in Qingdao Municipal Hospital,Shandong Province from May 2020 to December 2023 were selected.According to the occurrence of CNR,AMI patients were divided into CNR group(18 cases)and coronary reflow group(62 cases).The serum levels of lncRNA HOTAIR and lncRNA SNHG16 were detected before PCI.The clinical data of the two groups were compared,and the influ-encing factors of CNR during PCI were analyzed.The receiver operating characteristic curve was used to analyze the value of lncRNA HOTAIR and lncRNA SNHG16 in predicting CNR in AMI patients during PCI.Results The time from onset to PCI ≥6 h,the proportion of lesion vessel length ≥20 mm,and the expression level of serum lncRNA SNHG16 in the CNR group were higher than those in the coronary reflow group,and the expression level of serum lncRNA HOTAIR was lower than that in the coronary reflow group(all P＜0.05).Logistic regression analysis showed that the length of diseased vessels ≥20 mm and high lncRNA SNHG16 were risk factors for CNR in AMI patients undergoing PCI,and high lncRNA HOTAIR was a protective factor for CNR in AMI patients undergoing PCI(all P＜0.05).The area under the curve of lncRNA HOTAIR and lncRNA SNHG16 in predicting CNR in AMI patients during PCI was 0.726 and 0.735,respectively,and the area under the curve of the combination of lncrna HOTAIR and lncrna SNHG16 was 0.947,which was higher than that of single prediction(Z=2.560,P=0.011;Z=3.035,P=0.002).Conclusion The decreased expression of lncRNA HOTAIR in AMI patients,and the increased expression of lncRNA SNHG16 is related to the CNR during PCI,which can be used as a marker to predict the CNR during PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionCoronary no-reflowLong non-coding RNAHOX transcript antisense RNASmall nucleolar RNA host gene 16
Publication Date：2025-10-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1460-1464 )