The application value of white blood cell subsets to high-density lipoprotein cholesterol ratio in the risk prediction and risk stratification of coronary atherosclerotic heart disease

Xu Shuangshuang; Han Jie; Tao Weiwei

doi:10.3760/j.issn.1673-4777.2025.10.003

Abstract：Objective To investigate the application value of monocyte to high-density lipoprotein choles-terol ratio(MHR),neutrophil to high-density lipoprotein cholesterol ratio(NHR)and lymphocyte to high-density lipoprotein cholesterol ratio(LHR)in risk prediction and risk stratification of coronary atherosclerotic heart disease(CHD).Methods A total of 200 patients who underwent coronary angiography in the Affiliated Hospital of Nanjing University of Chinese Medicine from March 2022 to June 2024 were selected.According to the results of coronary angiography,the patients were divided into CHD group(120 cases)and non-CHD group(80 cases),and the CHD group was further divided into low-risk group(80 cases)and medium-high-risk group(40 cases)according to SYNTAX score.The clinical data of patients were collected,and the relationship between MHR,NHR,LHR and the degree of coronary artery stenosis was analyzed.Multivariate Logistic regression was used to analyze the independent risk factors of CHD,and the receiver operating characteristic(ROC)curve was used to evaluate the predictive value of each index for CHD.Results The MHR,NHR and LHR of the CHD group were significantly higher than those of the non-CHD group[(0.42±0.15)vs(0.28±0.11),(3.79±1.62)vs(2.45±0.88),(1.49±0.58)vs(1.29±0.50)](all P＜0.05).Spearman correlation analysis showed that MHR,NHR and LHR were significantly positively correlated with SYNTAX score(r=0.460,0.496,0.156,all P＜0.05).Multivariate Logistic regression analysis showed that history of hypertension,history of diabetes,history of smoking,MHR,NHR and low-density lipoprotein cholesterol were independent risk factors for CHD(all P＜0.05).ROC curve results showed that the area under the curve of MHR,NHR and combined detection for predicting CHD were 0.785,0.790 and 0.826,respectively;the sensitivity were 81.7％,75.0％and 74.2％,and the specificity were 68.7％,73.8％and 81.2％,respectively.Conclusion Both MHR and NHR are independent risk factors for CHD,and are significantly positively correlated with the degree of coronary artery stenosis.The predictive value of combined detection for CHD is better than that of single detection,which has important clinical application value.