Research progress on the mechanism of microRNA in the occurrence and development of ischemic stroke
Wu Mingchang
Yu Yunda
Long Faqing
Abstract：Ischemic stroke(IS)is one of the most important diseases leading to death and long-term disability worldwide.In recent years,microRNA(miR),as an important gene expression regulator,has attracted extensive attention in its role in IS.MiR plays a variety of roles in stroke pathology and repair by regulating inflam-mation,apoptosis,blood-brain barrier permeability,neuronal survival and synaptic plasticity.Studies have shown that miR has bidirectional regulatory properties,which can not only aggravates ischemic brain damage(for example,miR-155,miR-34a),but also reduce brain damage and promote repair(for example,miR-21,miR-124,miR-132).In addition,miR plays a dynamic role in different stages and different pathological mechanisms of stroke,which provides a new perspective for the diagnosis and treatment of stroke.This review systematically summarized the mechanism of miR in IS,focusing on its regulatory role in inflammatory response,oxidative stress,apoptosis,blood-brain barrier injury and brain edema,and neural network repair.In addition,the limitations of current research were analyzed and future development directions were prospected.
Keywords：Ischemic strokeMicroRNAMechanism researchInflammatory responseNerve repairTherapeutic target
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1426-1430 )