Effect of warming acupuncture combined with Yiqi Tongluo recipe in the treatment of stroke of Qi deficiency and blood stasis type in the recovery period and its influence on cerebral hemodynamics and neurological function

Chen Yaling; Tang Shuxiao; Zhou Fen; Zeng Meiqi; Shi Xiaoxuan; Liao Ling

doi:10.3760/j.issn.1673-4777.2025.09.026

Abstract：Objective To explore the clinical effect of warming acupuncture combined with Yiqi Tongluo recipe in the treatment of stroke of Qi deficiency and blood stasis type patients in the recovery stage and its influence on cerebral hemodynamics,serum phospholipase A2(PLA2)and homocysteine(Hcy)levels.Methods A total of 125 patients with stroke of Qi deficiency and blood stasis type in the recovery stage admitted to the First Hospital of Hunan University of Chinese Medicine from May 2022 to May 2024 were selected.According to the random number table method,they were divided into the control group(62 cases)and the observation group(63 cases).The control group was given routine treatment,and the observation group was treated with warming acupuncture combined with Yiqi Tongluo recipe on the basis of the control group.After two weeks of treatment,the efficacy of the two groups was evaluated,and the cerebral hemodynamic indexes,PLA2,Hey levels,neurological function-related factor levels and national institutes of health stroke scale(NIHSS)scores before and after treatment were compared.Results The total effective rate of the observation group was higher than that of the control group[93.6％(59/63)vs 80.6％(50/62)](P=0.030).After treatment,the cerebral vascular peripheral resistances of the two groups were lower than those before treatment,and that of the observation group was lower than that of the control group.The minimum blood flow and minimum blood flow velocity of the two groups were higher/faster than those before treatment,and those of the observation group were higher/faster than those of the control group(all P＜0.05).After treatment,the levels of serum PLA2 and Hey in the two groups were lower than those before treatment(both P＜0.05),and those in the observation group were lower than those in the control group[(16±4)mmol/L vs(19±5)mmol/L,(14.3±2.1)μmol/L vs(17.5±3.3)μmol/L](all P＜0.05).After treatment,the glial fibrillary acidic protein,neuron-specific enolase,myelin basic protein,brain-specific protein,heart-type fatty acid binding protein and NIHSS scores of the two groups after treatment were lower than those before treatment,and those of the observation group were lower than those of the control group(all P＜0.05).Conclusion Warming acupuncture combined with Yiqi Tongluo recipe can improve the curative effect of patients with stroke of Qi deficiency and blood stasis type in the recovery period,improve cerebral hemodynamics and neurological function,and reduce serum PLA2 and Hey levels.