The effect of Shenkang injection combined with levosimendan on cardiac and renal function and inflamma-tory indexes in patients with early acute kidney injury after coronary artery bypass grafting
Wang Huan
Qu Xiaoyu
Jiang Tao
Abstract：Objective To investigate the clinical effect of Shenkang injection combined with levosimendan on patients with early acute kidney injury(AKI)after coronary artery bypass grafting(CABG).Methods A total of 110 patients with early AKI after CABG admitted to General Hospital of Northern Theater Command of Chinese People's Liberation Army from February 2023 to September 2024 were selected.According to the random number table method,they were divided into control group and observation group,with 55 cases in each group.The control group was treated with levosimendan injection on the basis of conventional comprehensive treatment,and the observation group was treated with Shenkang injection on the basis of the control group.The clinical efficacy,cardiac function,renal function,inflammatory indicators and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[94.5％(52/55)vs 80.0％(44/55)](P=0.022).After treatment,the left ventricular fractional shortening,left ventricular ejection fraction,and glomerular filtration rate of the two groups were higher than those before treatment,and those of the observation group were higher than those of the control group.The levels of 24 h urine protein,urine microprotein,serum creatinine,blood urea nitrogen,interleukin-6(IL-6),IL-8,and IL-18 of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group(all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=1.000).Conclusion Shenkang injection combined with levosimendan in the treatment of patients with early AKI after CABG is effective,which can improve the heart and kidney function of patients,effectively inhibit the inflammatory response in the body,and is safe and reliable in clinical application.
Keywords：Acute kidney injuryCoronary artery bypass graftingShenkang injectionLevosimendanCardiac functionRenal functionInflammatory response
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1388-1392 )