Clinical study of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction
Zhang Jinliang
Wang Litao
Gao Zhao
Gao Peng
Abstract：Objective To investigate the clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction.Methods A total of 118 patients with acute myocardial infarction admitted to the Affiliated Hospital of Qingdao University from September 2023 to September 2024 were selected.They were divided into the observation group and the control group by envelope lottery method,with 59 cases in each group.The control group was treated with tirofiban,and the observation group was treated with Linaoxin capsule on the basis of the control group.The effects of the two groups were evaluated after 7 d of treatment.The clinical efficacy,cardiac function,myocardial injury markers,oxidative stress,vascular endothelial function and adverse reactions of the two groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group[91.5％(54/59)vs 76.3％(45/59)](P＜0.05).After treatment,the cardiac function indexes of left ventricular ejection fraction,stroke volume,cardiac output,and cardiac index in the observation group were higher than those in the control group,and the levels of serum creatine kinase isoenzyme,cardiac troponin Ⅰ,and myoglobin in the observation group were lower than those in the control group(all P＜0.05).After treatment,the levels of serum malondialdehyde and myeloperoxidase in the observation group were lower than those in the control group,and the level of superoxide dismutase was higher than that in the control group(all P＜0.05).After treatment,the vascular endothelial function indexes of nitric oxide,vascular endothelial growth factor and vascular endothelin-1 in the observation group were better than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction is significant,which can improve the cardiac function of patients,reduce the level of myocardial injury markers,inhibit the body's oxidative stress response,improve the vascular endothelial function of patients,and the treatment safety is good.
Keywords：Acute myocardial infarctionTirofibanLinaoxin capsuleCardiac functionOxidative stressVascular endothelial function
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1378-1382 )