Analysis of the expression of chromatin associated RNA 10 and 3-phosphoinositol-dependent protein kinase 1 and their evaluation value for the prognosis of patients with cervical cancer
Nuerziyan Litifu
Tao Ling
Huang Qian
Zou Junkai
Ayizhadan
Abstract：Objective To study the expression of long non-coding RNA chromatin associated RNA 10(CAR10)and 3-phosphoinositol-dependent protein kinase 1(PDPK1)in cervical cancer tissues and analyze the evaluation value of both for the prognosis of patients.Method A total of 136 patients with cervical cancer who were treated at Xinjiang Medical University Affiliated Cancer Hospital from January 2019 to February 2021 were selected.The relative expression levels of CAR10 and PDPK1 mRNA in cervical cancer tissues were detected by real-time fluorescence quantitative polymerase chain reaction.The correlation between CAR10 and PDPK1 mRNA was analyzed.Log-rank test was used to compare the survival curves of cervical cancer patients with different CAR10 and PDPK1 mRNA expression groups.Cox regression model was used to screen the prognostic factors of cervical cancer patients.Results The relative expression levels of CAR10 and PDPK1 mRNA in cervical cancer tissues were higher than those in adjacent tissues[(3.14±0.52)vs(1.01±0.28),(4.0±0.5)vs(1.1±0.3)](both P＜0.001).There was a positive correlation between CAR10 and PDPK1 mRNA expression in cervical cancer(r=0.789,95％confidence interval:0.347-0.897,P＜0.001).The mRNA levels of CAR10 and PDPK1 in international federation of gynecology and obstetrics(FIGO)stage Ⅰ B2-Ⅱ A2 cervical cancer were higher than those in stage Ⅰ A1-Ⅰ B1 patients(all P＜0.001).Log-rank test showed that the 3-year survival rate of different CAR10 and PDPK1 mRNA expression groups was statistically significant(all P＜0.05).Multivariate Cox regression analysis showed that FIGO stage Ⅰ B2-Ⅱ A2,high CAR10 mRNA and high PDPK1 mRNA were risk factors affecting the prognosis of cervical cancer patients(all P＜0.05).Conclusion The expressions of CAR10 and PDPK1 mRNA are significantly up-regulated in cervical cancer tissues,which are involved in the pro-gression of cervical cancer and are tumor markers for evaluating the prognosis of patients.
Keywords：Cervical cancerLong non-coding RNA chromatin associated RNA 103-phosphateinositol-dependent protein kinase 1Prognosis
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1364-1368 )