Effect of cyclosporine concentration on glucolipid and uric acid metabolism and renal function in patients with aplastic anemia

Gu Hongwei; Lu Jing; Hai Xin

doi:10.3760/j.issn.1673-4777.2025.09.014

Abstract：Objective To investigate the effects of different concentrations of cyclosporine on metabolism of blood glucose,blood lipid,uric acid,etc and renal function in patients with aplastic anemia.Methods A total of 143 patients with aplastic anemia treated with cyclosporine in the First Affiliated Hospital of Harbin Medical University from January 2021 to January 2024 were selected.According to the different blood drug concentration monitoring time,they were divided into 1 month after treatment group(group A,31 cases),3 months after treatment group(group B,34 cases)and 6 months after treatment group(group C,42 cases)and 12 months after treatment group(group D,36 cases).The blood concentration of cyclosporine,blood glucose,blood lipid,serum creatinine and uric acid of patients in different groups were collected,and the correlation between the blood concentration of cyclosporine and each index was analyzed.Results The blood concentrations of cyclosporine in groups A,B,C,and D were(193±28),(214±19),(188±28),and(176±26)μg/L,respectively.The blood concentration of cyclosporine in group B was higher than those in groups A,C,and D(P＜0.05).There were statistically significant differences in the levels of blood glucose,total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and creatinine among the four groups(all P＜0.05),and there was no statistically significant difference in the level of uric acid(P＞0.05).The results of correlation analysis showed that blood glucose,triglyceride,low-density lipoprotein cholesterol and creatinine were positively correlated with the blood concentration of cyclosporine,high-density lipoprotein cholesterol was negatively correlated with the blood concentration of cyclosporine(all P＜0.05),while total cholesterol and uric acid levels were not correlated with the blood concentration of cyclosporine(both P＞0.05).Conclusions The plasma concentration of cyclosporine has an effect on blood glucose,lipid metabolism and renal function in patients with aplastic anemia,but has no effect on uric acid metabolism.