Expression of α-thalassemia/X-linked mental retardation syndrome and telomerase reverse transcriptase gene mutation in different types of gliomas and their relationship with prognosis
Xiao Weihan
Shi Taozhen
Wang Zhen
Cheng Hai
Qiu Zili
Zhang Tong
Yin Luxin
Abstract：Objective To investigate the mutation of α-thalassemia/X-linked mental retardation syndrome(ATRX)and telomerase reverse transcriptase(TERT)gene in different types of gliomas,and to analyze the relationship between ATRX and TERT gene mutation and the prognosis of patients.Methods The clinical data of 117 patients with newly diagnosed glioma admitted to the Affiliated Hospital of Xuzhou Medical University from September 2021 to September 2024 were retrospectively analyzed.According to the postoperative pathological type,the patients were divided into glioblastoma group(61 cases),oligodendroglioma group(29 cases)and astrocytoma group(27 cases).The general clinical data and the positive rate of ATRX and TERT promoter mutation in each group were compared.Multivariate Cox regression model was used to analyze the factors affecting the prognosis of glioma patients.Kaplan-Meier survival curve was used to analyze the correlation between ATRX and TERT gene mutation and the prognosis of patients.Results The ATRX expression rates of oligodendroglioma group and astrocytoma group were higher than that of glioblastoma group[65.5％(19/29),63.0％(17/27)vs 36.1％(22/61)],the TERT promoter mutation rate in astrocytoma group was lower than those in glioblastoma group and oligodendro-glioma group[25.9％(7/27)vs 62.3％(38/61),79.3％(23/29)](all P＜0.05).Multivariate Cox regression analysis showed that ATRX and TERT promoter mutation were related factors affecting the prognosis of glioma patients(P＜0.05).Kaplan-Meier survival analysis showed that patients with ATRX loss had a shorter overall survival than those with ATRX expression[(29.1±1.3)months vs(34.2±0.8)months](Log-rank x2=4.835,P=0.028).The overall survival of patients with TERT promoter mutation was shorter than that of patients without TERT promoter mutation[(28.4±1.2)months vs(34.9±0.8)months](Log-rank x2=7.307,P=0.007).Conclusion ATRX expression and TERT promoter mutation are different in different types of gliomas.Loss of ATRX expression and TERT promoter mutation have a certain impact on the prognosis of glioma patients.
Keywords：Gliomaα-thalassemia/X-linked mental retardation syndromeTelomerase reverse tran-scriptaseGene mutationPrognosis
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1334-1338 )