The effect of allicin injection combined with conventional antibiotics in the treatment of patients with community-acquired pneumonia and its influence on antibiotics use density and bacterial clearance rate

Zhou Haijian; Pan Haiyan; Chen Donghua; Lyu Cong; Guo Lingxiao; Lu Haipeng; Mo Hailing

doi:10.3760/j.issn.1673-4777.2025.09.007

Abstract：Objective To investigate the effect of allicin injection combined with conventional antibiotics in the treatment of patients with community-acquired pneumonia(CAP)and its influence on antibiotics use density(AUD)and bacterial clearance rate.Methods Patients with CAP admitted to National Hospital of Guangxi Zhuang Autonomous Region from July 2022 to July 2024 were selected as the research objects.According to whether combined with allicin injection antibacterial treatment,they were divided into observation group(127 cases)and control group(167 cases).Based on the principle of propensity score matching,115 pairs of patients in the two groups were matched,of which 115 patients in the observation group were treated with conventional antibiotics combined with allicin injection,and 115 patients in the control group were treated with conventional antibiotics.The clinical efficacy,improvement of clinical symptoms,pathogen clearance rate,length of hospital stay,and AUD were compared between the two groups.Results There was no significant difference in the total effective rate of CAP patients between the two groups after antimicrobial treatment(P=1.000),but the clinical cure rate of the observation group was higher than that of the control group[30.4％(35/115)vs 14.8％(17/115)](P=0.005).After treatment,the pneumonia severity index and CURB-65 scores of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group(P＜0.05).There was no significant difference in the clearance rate of Klebsiella pneumoniae,Streptococcus pneumoniae,Staphylococcus aureus and Acinetobacter baumannii between the two groups after treatment(all P＞0.05).However,the overall pathogen clearance rate of the observation group was higher than that of the control group[98.3％(113/115)vs 87.8％(101/115)](P=0.002).The hospitalization time of the observation group was shorter than that of the control group[(6.0±1.8)dvs(9.7±2.4)d],and the AUD value was lower than that of the control group[(4.6±1.0)vs(7.7±1.7)](both P＜0.001).Conclusion Allicin injection combined with antibiotics in the treatment of CAP can significantly improve the clinical cure rate,improve the bacterial clearance rate,reduce AUD,and shorten the length of hospital stay.