Association between dietary index of gut microbiota and heart failure
Chen Siyuan
Yin Ning
Yang Hainan
Fan Qian
Abstract：Objective To investigate the association between dietary index of gut microbiota(DI-GM)and heart failure in a cross-sectional study.Methods The data of this study were collected from the United States National Health and Nutrition Examination Survey database 2007-2020.The inclusion criteria were 20-80 years old,33 665 subjects were included after excluding those missing information on heart failure,incomplete 2 d 24 h dietary recall,and missing data required for DI-GM calculation.DI-GM was calculated based on the data from two dietary retrospective interviews.Multivariate Logistic regression analysis was used to explore the relationship between DI-GM and heart failure.A restricted cubic spline model was constructed to determine the non-linear relationship between DI-GM and heart failure.Subgroup analysis by age,sex,etc.,and interaction was evaluated.Results A total of 33 665 participants were included in this study.The prevalence of heart failure was 3.3％(1 122 cases)and the weighted DI-GM score was 5(4,6).According to the presence or absence of heart failure,the patients were divided into heart failure group and non-heart failure group.There were significant differences in age,gender,race,education level,marital status,family income/poverty line,body mass index,health behavior,and disease history between the heart failure group and the non-heart failure group(all P＜0.05),and the weighted score of DI-GM in the heart failure group was lower than that in the non-heart failure group(P=0.002).The results of weighted multivariate Logistic regression analysis showed that after adjusting for covariates in different models,the increase in DI-GM was associated with a reduced risk of heart failure(all P＜0.05).The DI-GM subgroup analysis showed that the risk of heart failure decreased with the increase of scores(the P-values for trend were all less than 0.001).The restricted cubic spline model showed a linear association between DI-GM and the risk of heart failure(nonlinearity test P=0.522).Subgroup analysis showed no significant interaction between DI-GM and heart failure in each subgroup(all P＞0.05).Conclusion DI-GM is independently associated with the risk of heart failure,and high level of DI-GM has a protective effect on heart failure.
Keywords：Dietary index of gut microbiotaHeart failureCross-sectional studyUnited States National Health and Nutrition Examination Survey
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1299-1303 )