The relationship between D-dimer/fibrinogen ratio and C-reactive protein/fibrinogen ratio and clinical prognosis in elderly patients with acute exacerbation of chronic heart failure
He Cui
Zhang Xiaoling
Abstract：Objective To investigate the relationship between D-dimer/fibrinogen ratio(DFR)and C-reactive protein/fibrinogen ratio(CFR)and clinical prognosis in elderly patients with acute exacerbation of chronic heart failure(AECHF).Methods The clinical data of 157 patients with AECHF admitted to Chongqing University Fuling Hospital from May 2020 to May 2024 were retrospectively collected.DFR and CFR were calculated,and the death and rehospitalization due to heart failure within 90 days after admission of AECHF patients were counted.According to the prognosis of AECHF patients,they were divided into good prognosis group(105 cases)and poor prognosis group(52 cases).The risk factors for the poor prognosis of patients with AECHF were analyzed,and the value of DFR and CFR in predicting the poor prognosis of patients with AECHF was analyzed.Results DFR and CFR in the poor prognosis group were higher than those in the good prognosis group[(0.20±0.05)vs(0.18±0.03),(3.3±0.7)vs(2.6±0.4)](both P＜0.05).New York Heart Association class Ⅳ,N-terminal pro-brain natriuretic peptide(NT-proBNP),DFR and CFR were risk factors for poor prognosis in patients with AECHF(all P＜0.05).The area under the ROC curve of combined DFR,CFR and NT-proBNP for predicting poor prognosis in AECHF patients was higher than that of DFR,CFR or NT-proBNP alone(Z=3.861,3.452,2.853,all P＜0.05).Conclusion Increased DFR and CFR are associated with poor prognosis in patients with AECHF.The combination of DFR,CFR and NT-proBNP has a high prognostic value in patients with AECHF.
Keywords：Acute exacerbation of chronic heart failureD-dimer/fibrinogen ratioC-reactive protein/fibrinogen ratio
Publication Date：2025-09-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1294-1298 )