Observation on therapeutic effect of modified Buyang Huanwu decoction in relieving chemotherapy related peripheral neurotoxicity of advanced triple negative breast cancer
Su Fei
Lou Yanni
Cheng Zhiqiang
Wan Donggui
Abstract：Objective To investigate the clinical effect and safety of modified Buyang Huanwu decoction combined with chemotherapy in the treatment of advanced triple negative breast cancer(TNBC).Methods The clinical data of 162 hospitalized patients diagnosed with advanced TNBC and received chemotherapy in China-Japan Friendship Hospital from January 2021 to January 2024 were retrospectively analyzed.According to the different treatment regimens,the patients were divided into simple chemotherapy group(treated with albumin-bound paclitaxel,eutidrone or capecitabine standard chemotherapy)and integrated traditional Chinese and western medicine treatment group(treated with modified Buyang Huanwu decoction combined with standard chemotherapy),with 81 cases in each group.The clinical efficacy,adverse reactions and quality of life in terms of pain were observed after treatment.Results The proportion of stable disease and disease control rate in the integrated traditional Chinese and western medicine treatment group were higher than those in the simple chemotherapy group[24.5％(19/81)vs 12.3％(10/81),69.1％(56/81)vs 50.6％(41/81)](both P＜0.05).The progression-free survival of the integrated traditional Chinese and western medicine treatment group was longer than that of the simple chemotherapy group[(4.6±1.9)months vs(4.0±1.6)months](P＜0.05).After 3 months of treatment,the total effective rate of peripheral neurotoxicity in the integrated traditional Chinese and western medicine treatment group was higher than that in the simple chemotherapy group[91.8％(45/49)vs 90.8％(59/65)](P＜0.05).After the last chemotherapy and at the 3-month follow-up,the pain numerical rating scale score of the integrated traditional Chinese and western medicine treatment group was lower than that of the simple chemotherapy group[(1.2±0.8)vs(2.9±1.0),(1.4±0.7)vs(2.5±1.2)](both P＜0.05).Conclusion Buyang Huanwu decoction combined with chemotherapy has a good clinical effect in the treatment of advanced TNBC,and it can significantly reduce chemotherapy-related peripheral neurotoxicity and improve the quality of life of patients with advanced TNBC.
Keywords：Triple negative breast cancerInvigorating Qi and activating blood prescriptionsBuyang Huanwu decoctionChemotherapy
Publication Date：2025-08-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1233-1237 )