The clinical efficacy and safety of Zhenzhu Tongluo pill in the treatment of pain caused by spinal cord,root nerve and cauda equina nerve compression
Zhou Lin
Zhang Kaibo
Wang Xiaohui
Dong Pengfei
Wang Dan
Abstract：Objective To evaluate the clinical efficacy and safety of Zhenzhu Tongluo pill in the treatment of pain caused by spinal cord,root nerve and cauda equina nerve compression.Methods A randomized,double-blind,placebo-controlled trial was conducted to select 160 patients aged 25-65 years who were diagnosed with pain caused by spinal cord,root nerve,or cauda equina nerve compression and treated at the First Affiliated Hospital of Zhengzhou University from August to October 2024.The patients were randomly divided into the observation group and the control group by computer randomization method,with 80 cases in each group.The observation group was given Zhenzhu Tongluo pill on the basis of conventional medication,and the control group was given placebo on the basis of conventional medication.The course of treatment was 12 weeks for both groups.The visual analogue scale(VAS)score,modified Japanese Orthopaedic Association Evaluation of Treatment Score(mJOA),Short Form Health Survey(SF-36)scores,pain relief time,efficacy and safety were compared between the two groups before and after treatment.Results After 4,8 and 12 weeks of treatment,the VAS scores of the two groups were lower than those before treatment,the mJOA scores were higher than those before treatment,the VAS scores of the obser-vation group at each time point were significantly lower than those of the control group,and the mJOA scores were higher than those of the control group(all P＜0.05).After 12 weeks of treatment,the SF-36 scores of the two groups were higher than those before treatment,and the SF-36 score of the observation group was significantly higher than that of the control group(all P＜0.05).The pain relief time of the observation group was significantly shorter than that of the control group(P＜0.001).The total effective rate of the observation group was significantly higher than that of the control group[83.8％(67/80)vs 38.8％(31/80)](P＜0.001).Before and after treatment,the blood routine,urine routine,liver and kidney function,and coagulation function of patients in the two groups were within the normal range.Conclusion Zhenzhu Tongluo pill has significant effect and good safety in the treatment of pain caused by spinal cord,root nerve or cauda equina nerve compression,which provides a strong basis for clinical treatment.
Keywords：Spinal cord compressionRoot nerve compressionCauda equina nerve compressionZhenzhu Tongluo pillPain
Publication Date：2025-08-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1228-1232 )