The effect of Shengui capsule combined with sacubitril/valsartan sodium in the treatment of chronic heart failure and its influence on serum angiotensin Ⅱ and brain natriuretic peptide levels

Liang Xiaoqian; Zhang Jiwei; Liu Hongtao

doi:10.3760/j.issn.1673-4777.2025.08.020

Abstract：Objective To investigate the clinical effect of Shengui capsule combined with sacubitril/valsartan sodium in the treatment of chronic heart failure and its effect on serum angiotensin Ⅱ(Ang Ⅱ)and brain natriuretic peptide(BNP)levels.Methods A total of 128 patients with chronic heart failure admitted to Hebei Chest Hospital from July 2023 to May 2024 were selected.They were divided into single drug group and combined group by simple random method,with 64 cases in each group.The single drug group was treated with sacubitril/valsartan sodium,and the combined group was treated with Shengui capsule on the basis of the single drug group.The treatment effect,Ang Ⅱ,BNP,cardiac function,oxidative stress level,Lee's heart failure score and heart failure self-care index(SCHFI)score were compared between the two groups.Results After treatment,the total effective rate of the combined group was higher than that of the single drug group[92.2％(59/64)vs 78.1％(50/64)](P=0.025).After treatment,the serum levels of Ang Ⅱ and BNP in the two groups were lower than those before treatment,and those in the combined group were lower than those in the single drug group[(25.1±2.7)ng/L vs(28.7±3.0)ng/L,(143±15)ng/L vs(169±17)ng/L](all P＜0.05).After treatment,the left ventricular ejection fraction,superoxide dismutase,glutathione peroxidase and SCHFI score of the two groups were higher than those before treatment,and those of the combined group were higher than those of the single drug group(all P＜0.05).The left ventricular posterior wall thickness,malondialdehyde level and Lee's heart failure score in the two groups were lower than those before treatment,and those in the combined group were lower than those in the single drug group(all P＜0.05).Conclusion Shengui capsule combined with Sacubitril/valsartan sodium is effective in the treatment of chronic heart failure,which can effectively improve cardiac function and dyspnea.