The effect of methylprednisolone pulse therapy combined with mouse nerve growth factor on visual acuity and autoimmune antibodies levels in patients with acute optic neuritis

Chen Peng; Zhao Xin; Shao Chensha

doi:10.3760/j.issn.1673-4777.2025.08.019

Abstract：Objective To investigate the effect of methylprednisolone pulse therapy combined with mouse nerve growth factor on visual acuity and autoimmune antibodies levels in patients with acute optic neuritis.Methods A total of 122 patients with acute optic neuritis admitted to Affiliated Hospital of Hebei University from July 2023 to June 2024 were selected as the research objects.According to the random number table method,they were divided into the control group(61 cases)and the observation group(61 cases).Both groups were given conventional treatment first,the control group was given mouse nerve growth factor,and the observation group was given methylprednisolone pulse therapy on the basis of the control group,both groups were treated for 4 weeks.The curative effect,visual acuity,visual function index,visual field defect value,autoimmune antibody,visual evoked potential,incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[91.8％(56/61)vs 77.0％(47/61)](x2=5.050,P=0.025).After treatment,the visual acuity,visual function index and P100 wave amplitude of the two groups were higher/greater than those before treatment,and those of the observation group were higher/greater than those of the control group;the visual field defect value,positive rate of myelin oligoden-drocyte glycoprotein,positive rate of aquaporin 4,and P100 wave latency in the two groups were lower/shorter than those before treatment,and those in the observation group were lower/shorter than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(x2=0.684,P=0.408).The recurrence rate of the observation group was lower than that of the control group[8.2％(5/61)vs 21.3％(13/61)](x2=4.171,P=0.041).Conclusion Methylprednisolone pulse therapy combined with mouse nerve growth factor has a significant effect on acute optic neuritis,which can effectively improve visual acuity,improve the function of the optic nerve,and reduce the immune response.