Analysis of pathological and clinical characteristics of postmenopausal abnormal uterine bleeding
Zhang Caizhi
Huang Jinyuan
Cao Yuting
Wu Jianhong
Dai Yinmei
Abstract：Objective To observe the pathological types and distribution of abnormal uterine bleeding in postmenopausal women,analyze the relationship between different pathological types and clinical characteristics,and explore the risk factors of endometrial malignant and precancerous lesions in postmenopausal women with abnormal uterine bleeding.Methods The clinical data of 894 patients with postmenopausal abnormal uterine bleeding who underwent hysteroscopy and endometrial localization biopsy in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from May 1,2018 to May 1,2023 were retrospectively analyzed.The pathological and clinical characteristics of the patients were summarized.Multivariate Logistic regression was used to analyze the risk factors of endometrial malignant and precancerous lesions in postmenopausal women with abnormal uterine bleeding.Results Among 894 patients with abnormal uterine bleeding after menopause,the pathological types were mainly benign lesions,accounting for 710 cases(79.4％),of which endometrial polyps accounted for the largest proportion,269 cases(30.1％),malignant and precancerous lesions accounted for 184 cases(20.6％),and endometrial cancer was the most common,accounting for 151 cases(16.9％).There were significant differences between the two groups in age,menopausal years,fertility,diabetes mellitus,endometrial echo uniformity,endometrial thickness ≥0.5 cm,duration of abnormal uterine bleeding,normal coagulation function and normal proportion of tumor markers(all P＜0.05).Multivariate Logistic regression analysis showed that long menopausal years(6-10 years,＞10 years),non-childbearing,endometrial thickness ≥0.5 cm,abnormal tumor markers were the risk factors for endometrial malignant and precancerous lesions in postmenopausal patients(all P＜0.05).Conclusion The main cause of abnormal uterine bleeding after menopause is benign lesions,and the occurrence of malignant and precancerous lesions is related to the years of menopause,fertility,endometrial thickness and tumor markers.
Keywords：Abnormal uterine bleeding after menopauseEndometrial malignant lesionsHigh-risk factorsClinical features
Publication Date：2025-08-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1204-1208 )