Analysis of the current status of outcome indicators of randomized controlled trials of exercise therapy intervention in chronic kidney disease
Liu Yu
Li Jing
Yue Shujie
Fang Xiaoyue
Ke Chenghao
Abstract：Objective To analyze the current status of randomized controlled trials(RCT)of exercise therapy in the treatment of chronic kidney disease(CKD),and to provide suggestions for the evaluation method of clinical effect of exercise therapy in the treatment of CKD.Methods A number of Chinese and English databases were systematically searched for RCT of exercise intervention in CKD from the establishment of the database to March 2025.The characteristics of the literature were extracted,and the selection of outcome indicators of RCT of exercise intervention in CKD was analyzed.Results A total of 52 articles were included,involving 58 outcome indicators that appeared twice or more,and a total of 406 reports were reported.The outcome indicators included renal function(66 times,16.3％),exercise ability test(34 times,8.4％),physical function performance(60 times,14.8％),risk factors(135 times,33.2％),and pathogenesis related indicators(66 times,16.3％),questionnaires and scales(20 times,4.9％),and safety indicators(25 times,6.2％).Conclusion The outcome indicators of RCT on exercise intervention in CKD have some problems,such as large selection differences,some outcome indicators need to be improved,and less attention is paid to clinical symptoms and mental health.Future research should be committed to building a core index set to make the selection of indicators scientific,representative and clinical practicability,and improve the rigor of outcome indicators.
Keywords：Chronic kidney diseaseExercise therapyRandomized controlled trialOutcome indicators
Publication Date：2025-08-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1175-1179 )