Clinical observation of different doses of lauromacrogol sclerotherapy for hemorrhagic internal hemor-rhoids
Wan Yuxin
Gao Shan
Abstract：Objective To investigate the differences of intraoperative related indicators,clinical efficacy,safety,postoperative quality of life and patient satisfaction between low-dose(0.2-＜0.5 ml)and standard-dose(0.5-1.5 ml)lauromacrogol sclerotherapy in the treatment of hemorrhagic internal hemorrhoids,in order to provide scientific basis and reference for clinical practice.Methods A total of 137 patients with hemorrhagic internal hemorrhoids who received lauromacrogol sclerotherapy in Xiangyang Central Hospital,Hubei Province from January 2021 to November 2024 were selected.According to the single injection dose,they were divided into standard-dose group(99 cases)and low-dose group(38 cases).The intraoperative indicators,postoperative complications,clinical efficacy,quality of life and patient satisfaction were compared between the two groups.Results The operation time,average dose of single injection point and total injection volume in the low-dose group were shorter/less than those in the standard-dose group[(23±3)min vs(25±4)min,(0.46±0.08)ml vs(0.95±0.33)ml,(1.8±0.6)ml vs(4.4±1.9)ml](all P＜0.05).The incidences of postoperative dirt and anal distension in the low-dose group were significantly lower than those in the standard-dose group(both P＜0.05).At least 8 weeks of follow-up,the incidences of bleeding and prolapse in the standard-dose group were higher than those in the low-dose group(both P＜0.05).There was no significant difference in the total effective rate between the standard-dose group and the low-dose group[99.0％(98/99)vs 100.0％(38/38)](P=0.303).The low-dose group performed better than the standard-dose group in mobility,self-care ability,and daily activities(all P＜0.05).Patients in the low-dose group were more satisfied than those in the standard-dose group(P=0.02).Conclusion For patients with hemorrhagic internal hemorrhoids,endoscopic single-point injection of low-dose and standard-dose lauromacrogol has the same effect,and has fewer postoperative complications,better quality of life,and higher patient satisfaction.
Keywords：Hemorrhagic internal hemorrhoidsLauromacrogolSclerotherapyDrug dosage
Publication Date：2025-08-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1169-1174 )