Analysis of the relationship between antinuclear antibody,antinuclear antibody spectrum,and antiphos-pholipid antibody and adverse pregnancy outcomes,as well as medication use

Tang Zhiya; Fu Ping

doi:10.3760/j.issn.1673-4777.2025.07.019

Abstract：Objective To investigate the relationship between antinuclear antibody,antinuclear antibody spectrum(ANAs),antiphospholipid antibodies(aPLs)and adverse pregnancy outcomes,and analyze the medication use.Methods The clinical data of 153 pregnant patients with positive antinuclear antibodies,ANAs or aPLs in the Second Affiliated Hospital of Kunming Medical University from January 2021 to May 2024 were retrospectively collected.The pregnancy outcomes were recorded,and the patients with adverse pregnancy outcomes were included in the observation group(80 cases),and the rest of the patients with good pregnancy outcomes were included in the control group(73 cases).The clinical data,antinuclear antibodies,ANAs,aPLs and medication during pregnancy were compared between the two groups.The binary Logistic regression model was used to analyze the risk factors of adverse pregnancy outcomes.Results There were significant differences in the history of previous pregnancy loss,gestational age,gravidity,proportion of cesarean section and neonatal admission to the neonatal department between the two groups(all P＜0.05).The positive rates of antinuclear antibody,anti-SSA antibody,anticardiolipin antibody,anti-β2 glycoprotein Ⅰ antibody(aβ2GPI)and antinuclear antibody combined with SSA in the observation group were higher than those in the control group(all P＜0.05).The proportion of drugs used during pregnancy in the observation group was lower than that in the control group[75.0％(60/80)vs 90.4％(66/73)](x2=6.238,P=0.013).Binary Logistic regression analysis showed that neonatal admission to the neonatal department,positive antinuclear antibody and positive aβ2GPI were risk factors for adverse pregnancy outcomes,and gestational age was a protective factor(all P＜0.05).Conclusion Abnormal antinuclear antibodies,ANAs and aPLs are found in pregnant patients.Early intervention and timely drug treatment should be used to reduce the occurrence of adverse pregnancy outcomes and ensure the safety of mother and child.