Analysis of the clinical characteristics and surgical method selection of patients with mitral valve prolapse
Cai Xuemin
Li Bing
Xue Jia
Feng Yangyang
Han Jiancheng
Yao Yan
Abstract：Objective To explore the clinical characteristics of patients with mitral valve prolapse(MVP)and the related factors of surgical method selection.Methods The clinical data of 1 015 MVP patients who underwent surgical operations at Beijing Anzhen Hospital,Capital Medical University from January 1,2018 to December 31,2023 were collected for retrospective analysis.According to the different surgical methods,they were divided into the formation group(662 cases)and the replacement group(353 cases).The baseline data of the patients at admission and the information of transthoracic echocardiography were collected.The clinical characteristics of the two groups of patients were compared,and the related factors of the surgical method selection of MVP patients were analyzed.Results The age of patients in the formation group was younger than that in the replacement group,and the proportions of coronary atherosclerotic heart disease,diabetes mellitus,and hyperlipidemia were lower than those in the replacement group;the levels of D-dimer,C-reactive protein(CRP)and brain natriuretic peptide(BNP)were all lower than those in the replacement group,while the estimated glomerular filtration rate level was higher than that in the replacement group(all P＜0.05).Among the 1 015 patients,768 cases(75.7％)underwent combined other cardiac surgeries simultaneously,and 317 cases(31.2％)underwent pathological examinations,among which 270 cases(85.2％)had myxoid degeneration.The left atrial inner diameter,left ventricular end-diastolic inner diameter and left ventricular end-systolic inner diameter in the formation group were smaller than those in the replacement group,and the left ventricular ejection fraction was higher than that in the replacement group[(45±8)mm vs(47±9)mum,(56±7)mm vs(57±8)mm,(36±6)mm vs(38±8)mm,(63±6)％vs(62±7)％](all P＜0.05).The results of binary Logistic stepwise forward regression analysis indicated that advanced age,higher CRP,and higher BNP were independent related factors for MVP patients to choose replacement surgery(all P＜0.05).Conclusions Among the patients who underwent surgical operation for MVP,those in the replacement group are older and had higher CRP and BNP levels,which might be a reference for clinicians' method selection on surgical methods.
Keywords：Mitral valve prolapseClinical characteristicsInfluencing factors
Publication Date：2025-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 978-981 )