Research progress on the regulatory mechanism of hepatocyte senescence in metabolic associated fatty liver disease
Yang Xueqing
Xu Rongyi
Li Xiaosi
Yu Jie
Qi Yan
Abstract：As an increasingly serious global health disease,metabolic associated fatty liver disease(MAFLD)has a rising incidence in young people,which seriously endangers human health and brings heavy economic burden to social development.In recent years,it has been found that hepatocyte senescence plays a non-negligible role in promoting liver lipid deposition,aggravating liver injury,and causing lipid metabolism disorders.At present,a summary review on the in-depth mechanism and drug intervention of hepatocyte senescence affecting the course of MAFLD is still insufficient,and the development of clinical treatment strategies is relatively lagging behind.This article focuses on the research progress of the regulatory mechanism of hepatocyte senescence in MAFLD from the perspective of the regulation of autophagy,DNA methylation changes,ferroptosis,effects on liver regeneration and drug mechanisms.This article aims to provide a reference for in-depth basic research,and provide a new perspective and practical guidance for the clinical treatment and drug development of MAFLD.
Keywords：Metabolic associated fatty liver diseaseHepatocyte senescenceAutophagyFerroptosisLiver regeneration
Publication Date：2025-06-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 950-954 )