Clinical study of Lingyang Qingfei pill combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia

Zhang Yun; Li Xinling; Li Li

doi:10.3760/j.issn.1673-4777.2025.06.019

Abstract：Objective To investigate the effect of Lingyang Qingfei pill combined with piperacillin sodium and tazobactam sodium in the treatment of patients with severe pneumonia.Methods A total of 125 patients with severe pneumonia admitted to the General Hospital of the Northern Theater Command of Chinese People's Liberation Army from October 2020 to October 2023 were selected as the research objects.According to the random number table method,they were divided into the control group(62 cases)and the observation group(63 cases).All patients were given conventional treatment.The control group was treated with piperacillin sodium and tazobactam sodium,and the observation group was treated with Lingyang Qingfei pill on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy,symptom disappearance time,pulmonary function index,inflammatory factor index and safety of the two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group[96.8％(61/63)vs 74.2％(46/62)](x2=12.985,P＜0.001).After treatment,the antipyretic time,shortness of breath disappearance time,cough disappearance time and wet rales disappearance time of the observation group were shorter than those of the control group(all P＜0.05).After treatment,the forced vital capacity,forced expiratory volume in the first second and partial expiratory flow-volume of the two groups were higher than those before treatment,and those of the observation group were higher than those of the control group(all P＜0.05).After treatment,the levels of serum C-reactive protein,interleukin-6 and procalcitonin in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group[7.9％(5/63)vs 4.8％(3/62)](x2=0.501,P=0.479).Conclusion Lingyang Qingfei pill combined with piperacillin sodium and tazobactam sodium has a good effect on severe pneumonia,which can relieve clinical symptoms,improve lung function,reduce inflammatory factors,and has good safety.