Effects of gabapentin on preoperative anxiety and intubation response in patients with human immunodefi-ciency virus infection

Dong Ping; Niu Shaoning; Zhao Liqin; Zhao Nana; Liu Xinna; Cheng Hao

doi:10.3760/j.issn.1673-4777.2025.06.017

Abstract：Objective To investigate the effect of gabapentin on preoperative anxiety and intubation reaction in patients with human immunodeficiency virus(HIV)infection.Methods A total of 68 HIV-infected patients who underwent elective general anesthesia and non-cardiac surgical treatment at Beijing Ditan Hospital,Capital Medical University from May 2023 to November 2024 were selected.According to the random number table method,they were divided into the observation group and the control group,with 34 cases in each group.The control group received placebo orally the night before surgery,and the observation group was given gabapentin capsules orally the night before surgery.The visual analogue scale(VAS)score and state-trait anxiety questionnaire(STAI-S)score were compared between the two groups at the preoperative and immediately after entering the operating room.The heart rate and mean arterial pressure(MAP)were compared between the two groups before anesthesia induction,during tracheal intubation and 1,3,5,10 min after intubation.The occurrence of adverse reactions in the two groups was recorded.Results There was no significant difference in VAS scores between the two groups before operation,immediately into the operating room,and at the time of anesthesia recovery room(all P＞0.05).The STAI-S score in the observation group was lower than that before operation and that in the control group at the same time point[(39±5)vs(43±5)](all P＜0.05).The heart rate and MAP levels of the observation group were lower than those of the control group at the time of tracheal intubation and 1,3,10 min after intubation(all P＜0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(all P＞0.05).Conclusions Gabapentin can reduce preoperative anxiety and intubation reactions in HIV-infected patients,without prolonging the duration of stay in the anesthesia recovery room.