The effect of probucol combined with atorvastatin in the treatment of acute cerebral infarction and its effect on patients' blood lipids
Lu Xiuxiu
Yang Jianjun
Abstract：Objective To explore the effect of probucol combined with atorvastatin in the treatment of acute cerebral infarction and its effect on patients' blood lipids.Methods A total of 96 patients with acute cerebral infarction admitted to the Shandong Provincial Third Hospital from January 2022 to January 2024 were selected.They were divided into observation group and control group according to the random number table method,with 48 cases in each group.The control group was given conventional treatment based on atorvastatin,and the observation group was treated with probucol tablets on the basis of the control group.All patients were treated for 12 weeks.The clinical efficacy,blood lipid indexes,ultrasound parameters of carotid plaque,inflammatory factors,and treatment safety were compared between the two groups.Results The total effective rate of the obser-vation group was higher than that of the control group[91.7％(44/48)vs 72.9％(35/48)](P=0.016).After treatment,the blood lipid indexes of the two groups were better than those before treatment,and the blood lipid indexes of the observation group were better than those of the control group(all P＜0.05).After treatment,the carotid intima-media thickness and vascular resistance index of the observation group were less than those of the control group,and the maximum systolic velocity and the maximum end-diastolic velocity were higher than those of the control group(all P＜0.05).After treatment,the levels of inflammatory factors matrix metalloproteinase-2,nucleotide-binding oligomerization domain-like receptor protein 3 and interleukin-1 β in the observation group were lower than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Probucol combined with atorvastatin has a good application effect on acute cerebral infarction,which can improve the blood lipid level of patients,stabilize the carotid plaque of patients,improve the carotid blood flow velocity,reduce the level of inflammatory factors,and has good treatment safety.
Keywords：Acute cerebral infarctionProbucolAtorvastatinBlood lipid levelAtherosclerotic plaqueInflammatory factor
Publication Date：2025-06-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 841-845 )