Clinical significance of tumor-associated antigen in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis complicated with rapidly progressive interstitial lung disease
Lu Xuexia
Wang Zhixia
Dong Jingjing
Xu Xuelian
Li Yuting
Li Yunxia
Zhang Zhiqiang
Abstract：Objective To analyze the effect of tumor-associated antigens on the development of rapidly progressive interstitial lung disease(RP-ILD)in patients with anti-melanoma differentiation-associated gene 5(MDA5)antibody positive dermatomyositis.Methods Thirty-six patients with anti-MDA5 antibody positive dermatomyositis diagnosed in the First Affiliated Hospital of Xinxiang Medical University from August 2018 to July 2023 were retrospectively selected.The patients were divided into RP-ILD group(13 cases)and non-RP-ILD group(23 cases)according to whether RP-ILD occurred.The clinical data of the patients were collected,and Logistic regression analysis was used to evaluate the potential risk factors for RP-ILD in anti-MDA5 positive dermatomyositis patients.Results The levels of cytokeratin 19 serum fragment 21-1(CYFRA21-1)and carcino-embryonic antigen in the RP-ILD group were higher than those in the non-RP-ILD group(both P＜0.05).Multivariate Logistic regression model analysis was performed on CYFRA21-1 and carcinoembryonic antigen combined with gender,anti-Ro-52 antibody and ferritin,respectively,and it was found that CYFRA21-1[odds ratio=1.137,95％confidence interval(CI):1.028-1.258]and carcinoembryonic antigen(odds ratio=1.348,95％CI:1.057-1.718)were risk factors for the development of RP-ILD(both P＜0.05).Conclusions Elevated serum levels of CYFRA21-1 and CEA expression are associated with the risk of RP-ILD in anti-MDA5 antibody positive dermatomyositis patients.
Keywords：DermatomyositisAnti-melanoma differentiation-associated gene 5Rapidly progressing interstitial lung diseaseCarcinoembryonic antigenCytokeratin 19 serum fragment 21-1
Publication Date：2025-06-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 837-841 )