Research status of signaling pathways related to the pathogenesis of idiopathic pulmonary fibrosis
Zhang Lipeng
Wang Jing
Abstract：Idiopathic pulmonary fibrosis(IPF)is a fatal lung disease characterized by progressive fibrosis of lung tissue,and its pathogenesis is not fully understood.Recent studies have found that a variety of signaling pathways play a key role in the occurrence and progression of IPF.Including transforming growth factor β,Wnt/β-catenin,mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,Rho/Rho-associated kinase,Janus kinase/signal transducer and activator of transcription protein,mammalian target of rapamycin,etc.These pathways promote the process of pulmonary interstitial fibrosis by enhancing the proliferation,differentiation and extracellular matrix deposition of fibroblasts.However,many upstream and downstream signaling molecules have yet to be defined.In addition,cytokines such as vascular endothelial growth factor,fibroblast growth factor and platelet-derived growth factor also play an important role in the occurrence and development of IPF.An in-depth understanding of these signaling pathways and their interactions will help to provide new targets and strate-gies for early diagnosis and treatment of IPF.This article aims to summarize the current research progress and explore future research directions in order to provide a scientific basis for the clinical management of IPF.
Keywords：Idiopathic pulmonary fibrosisPathogenesisSignaling pathwaysResearch status
Publication Date：2025-05-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 776-780 )