Effect of Yiqi Wenyang Lishui therapy on serum uric acid level in patients with chronic heart failure complicated with hyperuricemia

Yang Yuanyin; Yuan Wangfei; Zheng Tao

doi:10.3760/j.issn.1673-4777.2025.05.022

Abstract：Objective To investigate the effect of traditional Chinese medicine therapy of Yiqi Wenyang Lishui on serum uric acid level in patients with chronic heart failure(CHF)complicated with hyperuricemia(HUA).Methods Totally 54 patients with CHF combined with HUA and Yang qi deficiency syndrome were selected from the Department of Cardiology,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from May 2021 to April 2023.The patients were divided into the control group(24 cases,treated with conventional western medicine)and the observation group(30 cases,treated with Yiqi Wenyang Lishui on the basis of conventional western medicine)according to whether they took traditional Chinese medicine.The serum uric acid levels of the two groups were compared after treatment.The relationship between serum uric acid level and age,gender,left ventricular ejection fraction(LVEF),New York Heart Association(NYHA)cardiac function classification,body mass index,whether complicated with hypertension,whether complicated with diabetes,whether with ischemic diseases history,whether taking anti-heart failure drugs,whether taking traditional Chinese medicine and other factors were analyzed.Results There was no significant difference in the level of uric acid between the two groups at baseline(P＞0.05).After treatment,the uric acid levels of the two groups were lower than those at baseline,and the decrease in the observation group was greater than that in the control group(all P＜0.05).After treatment,the serum uric acid level of the observation group decreased by 27.102 µmol/L more than that of the control group(β value was-27.102,95％confidence interval:-38.000--16.203,P＜0.001).The serum uric acid level of CHF patients with HUA was significantly positively correlated with age,LVEF,NYHA cardiac function classification,body mass index,and whether to take Yiqi Wenyang Lishui treatment traditional Chinese medicine(all P＜0.05).There was no significant correlation with gender,hypertension,diabetes,ischemic history,and use of anti-heart failure drugs(all P＞0.05).Conclusion Traditional Chinese medicine therapy of Yiqi Wenyang Lishui has a positive effect on improving serum uric acid level in CHF patients with HUA.