The effect of combined arrhythmia on clinical indicators and pregnancy outcomes of pregnant women

Yuan Yuan; Fu Yue; Zhang Jun; Gong Jing

doi:10.3760/j.issn.1673-4777.2025.05.018

Abstract：Objective To explore the situation of pregnancy complicated with arrhythmia and its influence on the pregnancy outcome of pregnant women,in order to provide new ideas and theoretical basis for clinical practice.Methods The clinical data of 287 pregnant women who delivered in the Department of Obstetrics,Beijing Anzhen Hospital,Capital Medical University from January 1,2019 to December 31,2023 were collected and analyzed retrospectively.The pregnant women were divided into arrhythmia group(142 cases)and non-arrhythmia group(145 cases)according to whether they were complicated with arrhythmia.The differences in general data,laboratory tests indicators and pregnancy outcomes between the two groups were compared.Results The maternal age,pre-pregnancy body mass index,gravidity and prevalence of congenital heart disease in the arrhythmia group were greater/higher/more than those in the non-arrhythmia group,while the maternal height and gestational age were lower/less than those in the non-arrhythmia group(all P＜0.05).There were no significant differences in pre-pregnancy body weight and parity between the two groups(both P＞0.05).The levels of creatine kinase isoenzyme,high-density lipoprotein cholesterol and C-reactive protein in the arrhythmia group were higher than those in the non-arrhythmia group(all P＜0.05).There was no significant difference in total cholesterol and low-density lipoprotein cholesterol between the two groups(all P＞0.05).The rates of cesarean section,premature delivery and postpartum hemorrhage in the arrhythmia group were higher than those in the non-arrhythmia group,and the rate of natural delivery was lower than that in the non-arrhythmia group[82.4％(117/142)vs 17.2％(25/145),33.1％(47/142)vs0(0),17.6％(25/142)vs 0(0),17.6％(25/142)vs 82.8％(120/145)](all P＜0.05).Conclusion Pregnant women with arrhythmia have an increased risk of adverse pregnancy outcomes such as cesarean section,postpartum hemorrhage,and premature delivery,which should be paid attention to in clinical practice.