Efficacy of Nocardia rubra cell wall skeleton in the treatment of female patients with persistent cervical high-risk human papillomavirus infection
Jia Hongxing
Wang Kefang
Abstract：Objective To investigate the clinical effect of Nocardia rubrum cell wall skeleton(Nr-CWS)topical treatment on women with cervical high-risk human papillomavirus(HR-HPV)persistent infection.Methods A total of 120 female patients with persistent cervical HR-HPV infection(≥ 1 year)who visited the gynecological clinic of Beijing Anzhen Hospital,Capital Medical University from January 2021 to August 2023 were collected,and the clinical data of the patients were collected for retrospective analysis.According to the patients'preferred treatment method,they were divided into observation group and control group,with 60 cases in each group.The control group was given lifestyle intervention,including healthy lifestyle,appropriate exercise,enhance body resistance;the patients in the observation group were treated with external application of Nr-CWS on the basis of immunity intervention,10 times as a course of treatment.The efficacy of the two groups was evaluated at 6 and 12 months after treatment.Results At 6 and 12 months after treatment,the total effective rate of the observation group was significantly higher than that of the control group[63.3％(38/60)vs 18.3％(11/60),73.3％(44/60)vs 35.0％(21/60)](all P＜0.05).There was no statistically significant difference in the efficacy(total effective rate)of different subtypes of persistent HR-HPV patients in the observation group at 6 and 12 months after treatment(all P＞0.05).Conclusion Topical Nr-CWS is effective in the treatment of persistent cervical HR-HPV infection in women.
Keywords：High-risk human papillomavirus infectionNocardia rubrum cell wall skeleton
Publication Date：2025-05-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 720-724 )