Study on the correlation between vascular senescence indexs and early disease progression of acute cerebral infarction

Ma Linying; Cui Xiaoyu; Deng Chunying; Zheng Jiao; Zuo Junqin; Liu Bin; Zhang Jinxia

doi:10.3760/j.issn.1673-4777.2025.05.010

Abstract：Objective To investigate the correlation between brachial-ankle pulse wave velocity(baPWV),cardio-ankle vascular index(CAVI),ankle-brachial vascular index(ABI)and early disease progression of acute cerebral infarction(ACI).Methods A total of 280 consecutive ACI patients hospitalized in the Department of Neurology,North China University of Science and Technology Affiliated Hospital from October 2023 to September 2024 were enrolled.According to the disease progression within 7 days of onset,the patients were divided into progression group(84 cases)and non-progression group(196 cases).The values of baPWV,CAVI and ABI were detected by arteriosclerosis monitoring device.The relationship between the three indexes and the early progression of ACI was analyzed,and the predictive value of the three indexes was discussed.Results The age,body mass index,fibrinogen,low-density lipoprotein cholesterol and lipoprotein associated phospholipase A2 in the progression group were higher/higher than those in the non-progression group(all P＜0.05).The baPWV and CAVI in the progression group were higher than those in the non-progression group,and ABI was lower than that in the non-progression group[(1 275±221)cm/s vs(919±124)cm/s,(10.8±0.8)vs(9.1±1.1),(0.82±0.10)vs(1.02±0.13)](t=13.901,14.729,13.076,all P＜0.001).Multivariate Logistic regression analysis showed that baPWV,CAVI,ABI,fibrinogen and lipoprotein-associated phospholipase A2 were independent influencing factors for early disease progression in patients with ACI(all P＜0.05).Among them,baPWV and CAVI were risk factors for the early progression of ACI,and ABI was a protective factor.Correlation analysis showed that baPWV and CAVI were positively correlated with the early progression of ACI(r=0.645,0.612,both P＜0.001),while ABI was negatively correlated with it(r=-0.621,P＜0.001).The area under the curve of baPWV,CAVI,ABI and their combination in predicting early disease progression were 0.906,0.886,0.891 and 0.946,respectively,and the combined detection of the three had higher predictive value.Conclusion The baPWV,CAVI and ABI are closely related to the early progression of ACI.The baPWV,CAVI and ABI all have predictive value for early disease progression in ACI patients,and the combined detection of the three has higher predictive value.