Study on the application effect and dose-effect relationship of oxycodone in CT-guided micro-coil puncture localization of pulmonary nodules

Jin Ruyi; Liu Xiaoyu; Zhang Minhao; Tan Jing; Gu Lianbing; Wang Lijun

doi:10.3760/j.issn.1673-4777.2025.05.008

Abstract：Objective To investigate the application effect and dose-effect relationship of oxycodone in CT-guided micro-coil puncture localization of pulmonary nodules.Methods A total of 125 patients who underwent CT-guided micro-coil puncture localization of pulmonary nodules in Jiangsu Cancer Hospital from December 2023 to June 2024 were selected.The patients were divided into control group and oxycodone 1,2,3 and 4 groups by random number table method,with 25 cases in each group.In the control group,the same volume of 0.9％sodium chloride solution was injected intravenously before the operation,and 1 mg/ml oxycodone hydrochloride injection 0.025 mg/kg,0.05 mg/kg,0.075 mg/kg,and 0.1 mg/kg were injected intravenously in oxycodone 1,2,3,and 4 groups before operation,respectively.The visual analogue scale(VAS)score during the peri-puncture period,the incidence of moderate and severe pain during the peri-puncture period,the basic vital signs at admission,before puncture,during puncture and at the end of puncture,the incidence of irritating symptoms during puncture,the success rate of one-time puncture and the incidence of adverse drug reactions were compared among the five groups.Results One patient in the oxycodone 2 group and one in the oxycodone 4 group were excluded from the study.The VAS scores of the control group and oxycodone 1,2,3,4 groups were(4.7±1.6),(3.9±1.5),(2.9±1.7),(1.6±1.4),and(1.4±1.1),respectively.The incidences of moderate and severe pain were 64.0％(16/25),56.0％(14/25),37.5％(9/24),8.0％(2/25),and 4.2％(1/24),respectively.The VAS scores of oxycodone 3 group and oxycodone 4 group were significantly lower than those of control group,oxycodone 1 group and oxycodone 2 group(all P＜0.05).The incidence of moderate to severe pain in oxycodone 3 group was significantly lower than that in control group and oxycodone 1 group(both P＜0.05).At the time of puncture,the heart rates of the oxycodone 3 groupand oxycodone 4 group were significantly lower than those of the control group and oxycodone 1 group(all P＜0.05).The incidences of respiratory incompliance and body movement in oxycodone 3 group and oxycodone 4 group were significantly lower than those in control group(all P＜0.05).The incidences of dizziness,nausea and vomiting in oxycodone 4 group were significantly higher than those in the other four groups(all P＜0.05).Conclusion Intravenous injection of 0.075 mg/kg and 0.1 mg/kg oxycodone during CT-guided micro-coil puncture positioning of pulmonary nodules can effectively reduce the pain of patients,reduce the incidence of moderate and severe pain during puncture,and significantly improve the cooperation of patients,among which 0.075 mg/kg oxycodone has fewer adverse drug reactions.