Efficacy and pharmacoeconomic evaluation of Jinwugutong capsule in the treatment of primary osteoporosis
Sun Yan
Xiao Peng
Liu Chuanhui
Wang Zhiwei
Abstract：Objective To investigate the effect of Jinwugutong capsule in the treatment of primary osteo-porosis and evaluate the drug economy.Methods A total of 200 patients with primary osteoporosis in Zhengzhou Orthopaedic Hospital,Henan Province from June 2022 to June 2023 were selected.According to the random number table method,they were divided into the control group and the observation group,with 100 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jinwugutong capsule on the basis of the control group.The two groups were evaluated and compared after 24 weeks of treatment.The traditional Chinese medicine syndrome score,low back pain and leg pain,activity of daily living scale(ADL)score,bone mineral density and bone metabolism indexes were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups,and the differences in clinical efficacy between the two groups were analyzed.The short-term drug economy of the two groups was evaluated.Results At 4,12 and 24 weeks after treatment,the traditional Chinese medicine syndrome scores of the observation group were lower than those of the control group(all P＜0.05).After treatment,the pain scores and ADL scores of the two groups were lower than those before treatment,and the bone mineral density was higher than that before treatment.The pain scores and ADL scores of the observation group were lower than those of the control group,and the bone mineral density was higher than that of the control group(all P＜0.05).After treatment,the levels of serum calcium,osteocalcin and total N-terminal propeptide of type Ⅰ collagen in the two groups were higher than those before treatment,and the serum phosphorus level was lower than that before treatment.The levels of serum calcium,osteocalcin and total N-terminal propeptide of type Ⅰ collagen in the observation group were higher than those in the control group,and the serum phosphorus level was lower than that in the control group(all P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group[2.0％(2/100)vs 14.0％(14/100)](P=0.002).The total effective rate of the observation group was higher than that of the control group[82.0％(82/100)vs 73.0％(73/100)](P=0.004).The cost-effectiveness ratio of the control group was 132.65,the effectiveness ratio of the observation group was 128.04,and the incremental cost-effectiveness ratio was 90.72.The treatment regimen in the observation group was more economical than that in the control group.Conclusion Jinwugutong capsule is effective in the treatment of primary osteoporosis,which can improve the traditional Chinese medicine syndrome score,relieve pain,improve bone metabolism,and is safe,reliable and more economical.
Keywords：OsteoporosisJinwugutong capsuleBone metabolism markersPharmacoeconomic evaluation
Publication Date：2025-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 597-602 )