Effect of Mongolian medicine Eridun Wurile on prothrombotic state and quality of life in elderly patients with hypertension

Narenmandula; Siqin; Yang Aomin

doi:10.3760/j.issn.1673-4777.2025.04.023

Abstract：Objective To investigate the effect of Mongolian medicine Eridun Wurile on prothrombotic state(PTS)and quality of life in elderly patients with hypertension.Methods From January 2023 to February 2024,60 elderly patients with hypertension were selected from the outpatient and inpatient Department of Mongolian Medicine,People's Hospital of Inner Mongolia Autonomous Region.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with amlodipine besylate tablets,and the observation group was treated with Mongolian medicine Eridun Wurile on the basis of the control group.Both groups were treated for 8 weeks.The levels of PTS molecular markers(four items of blood coagulation,D-dimer),quality of life scale scores,blood pressure and safety indicators were observed before and after treatment in the two groups.Results Among the 60 patients,1 case dropped out of the observation group,1 case was lost to follow-up in the control group,and 58 cases completed the trial,with a dropout rate of 3.3％(2/60).There were statistically significant differences in four items of coagulation and D-dimer before and after treatment in the observation group(all P＜0.05).After treatment,the differences of fibrinogen and D-dimer in the observation group were greater than those in the control group[1.46(1.23,1.85)g/L vs 0.06(0.02,0.14)g/L,0.16(0.13,0.22)mg/L vs 0.03(0.02,0.04)mg/L](both P＜0.05).There were statistically significant differences in systolic blood pressure and diastolic blood pressure in the two groups between before and after treatment(all P＜0.05).There were statistically significant differences in the scores of each dimension of the quality of life scale before and after treatment in the observation group(all P＜0.05).There were statistically significant differences in the scores difference before and after treatment of physiological symptoms,working status and interpersonal sensitivity between the two groups(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.313).Conclusions Mongolian medicine Eridun Wurile combined with amlodipine besylate tablets has a certain effect on the improvement of PTS molecular markers and quality of life in elderly patients with hypertension,and the improvement of fibrinogen,D-dimer,physiological symptoms,working status,interpersonal sensitivity and other indicators is significantly better than amlodipine besylate monotherapy.