Observation of clinical application effect of standardized intravenous nutrition formula for preterm infants

Wang Tiancheng; Li Shihong; Zheng Hailiang; Wang Yang; Xing Guirong; Li Li; Zhu Lulu; Zhang Hao; Zhang Li; Liu Ya

doi:10.3760/j.issn.1673-4777.2025.04.020

Abstract：Objective To observe the clinical effect of standardized intravenous nutrition formula in premature infants.Methods A total of 162 premature infants who needed parenteral nutrition and were hospitalized in Beijing Shijitan Hospital,Capital Medical University from July 2015 to March 2020 were enrolled in this study.According to the random number table method,they were divided into conventional solution group(80 cases)and standard solution group(82 cases).They were treated with individualized intravenous nutrition formula and standard intravenous nutrition formula with added L-carnitine,respectively.The two groups were compared in terms of general data,clinical conditions at 6 weeks after birth,and the incidence of such as cholestasis,bronchopulmonary dysplasia,intracranial hemorrhage,and retinopathy of prematurity.Results After 2 weeks of treatment,the weight gain of the standard solution group was greater than that of the conventional solution group[(151±92)gvs(110±78)g](P=0.003).At 6 weeks after birth,the levels of direct bilirubin and bile acid in the standard solution group were lower than those in the conventional solution group[(18±10)μmol/L vs(26±15)μmol/L,(53±27)μmol/L vs(77±24)μmol/L](both P＜0.001).At 36 weeks of gestation,the incidence of bronchop-ulmonary dysplasia was lower in the standard solution group than in the conventional solution group[12.2％(10/82)vs 27.5％(22/80)](P＜0.05).There was no significant difference in the incidence of intracranial hemorrhage and retinopathy of prematurity between the two groups(both P＞0.05).Conclusion Compared with individualized intravenous nutrition prescription,the weight gain of premature infants receiving standardized intravenous nutrition formula is better after 2 weeks.The use of standardized intravenous nutrition formula with L-carnitine is beneficial to reduce the degree of cholestasis in premature infants.The use of standardized intravenous nutrition is beneficial to reduce the incidence of bronchopulmonary dysplasia in preterm infants.There is no significant difference in the incidence of intracranial hemorrhage and retinopathy of prematurity between the two groups.