Efficacy and safety analysis of esketamine combined with sufentanil in patients undergoing liver cancer resection

Zhou Ruixin; Wang Hongtao; Wang Zhenyun; Zhang Jinguang; Pang Yuchi

doi:10.3760/j.issn.1673-4777.2025.04.014

Abstract：Objective To investigate the efficacy and safety of esketamine combined with sufentanil in patients undergoing liver cancer resection.Methods A total of 108 patients with primary liver cancer who under-went liver cancer resection in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Province from November 2021 to November 2023 were divided into sufentanil group and combination group by simple random method,with 54 cases in each group.Patients in both groups were treated with patient-controlled intravenous analgesia(PCIA)after operation.The sufentanil group was treated with sufentanil and ondansetron.The combination group was treated with esketamine on the basis of sufentanil group.The perioperative indexes,visual analogue scale(VAS)scores,respiratory and circulatory function indexes at 6,24 and 48 hours after operation were compared between the two groups.The occurrence of adverse reactions was recorded.Results The first ambulation time and the dosage of PCIA in the combined group were shorter/lower than those in the sufentanil group[(33±4)h vs(39±4)h,(56±5)ml vs(79±6)ml](both P＜0.001).The VAS scores of the two groups showed a decreasing trend at 6,24 and 48 hours after operation,and the VAS scores of the combined group were lower than those of the control group at each time point(all P＜0.001).The mean arterial pressure and heart rate of the two groups showed a decreasing trend,and the levels of the combined group were lower than those of the control group at each time point(all P＜0.001).The pulse oxygen saturation of the combined group was higher than that of the sufentanil group at each time point(all P＜0.05).The incidence of adverse reactions in the combined group was lower than that in the sufentanil group(P＜0.05).Conclusion PCIA with esketamine combined with sufentanil has definite analgesic effect in patients undergoing liver cancer resection,can improve perioperative indicators,and has little effect on respiratory and circulatory function of patients,with high safety.