Clinical characteristics and gender differences in patients with degenerative mitral regurgitation
Li Bing
Cai Xuemin
Xue Jia
Yao Yan
Han Jiancheng
Abstract：Objective To investigate the clinical characteristics and gender differences in patients with degenerative mitral regurgitation undergoing mitral valve repair.Methods A total of 639 consecutive patients with degenerative mitral regurgitation who underwent mitral valve repair in Beijing Anzhen Hospital,Capital Medical University from January 1,2018 to December 31,2022 were enrolled.The patients were grouped according to gender,and the differences in clinical characteristics and echocardiographic parameters between the two groups were compared.Results Of the 639 enrolled patients,195(30.5％)were female.Compared with male patients,female patients were older[58(47,66)years vs 54(45,62)years]and had higher levels of brain natriuretic peptide and D-dimer before surgery(all P＜0.05).There was no significant difference in the location of valve prolapse and chordae tendineae rupture between male and female patients(all P＞0.05).The left atrial antero-posterior diameter,right atrial diameter,left ventricular end-diastolic diameter and left ventricular end-systolic diameter of female patients were smaller than those of male patients(all P＜0.001).However,after adjusting for body surface area,the above imaging parameters were larger in female than in male,and the corrected left ventricular end-diastolic diameter and corrected left ventricular end-systolic diameter were significantly different(all P＜0.001).Conclusion For female patients with degenerative mitral regurgitation,ultrasound parameters without body surface area correction may underestimate the severity of cardiac compensation caused by valvular regurgitation.
Keywords：Degenerative mitral regurgitationMitral valve repairGender difference
Publication Date：2025-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 511-515 )