Analysis of left ventricular reverse remodeling at 1 year after transcatheter edge-to-edge repair of moderate to severe mitral regurgitation in patients with different etiologies
He Jing
Lu Zhinan
Ke Yutong
Liu Xinmin
Yuan Fei
Jiang Zhengming
Zhang Qian
Song Guangyuan
Abstract：Objective To evaluate the left ventricular reverse remodeling at 1 year after transcatheter edge-to-edge repair(TEER)of moderate to severe mitral regurgitation(MR)in patients with different etiologies.Methods The clinical and echocardiographic data of 91 patients with moderate to severe MR Who underwent TEER treatment in the Interventional Center of Valvular Heart Disease,Beijing Anzhen Hospital,Capital Medical University from June 2021 to November 2023 were retrospectively analyzed.According to the etiology,the patients were divided into degenerative mitral regurgitation(DMR)group(70 cases)and functional mitral regurgitation(FMR)group(21 cases).Clinical baseline data and echocardiographic data before and 1 year after surgery were collected.Left ventricular reverse remodeling and functional changes were compared between the two groups one year after surgery.Results Compared with the DMR group,the effective regurgitation orifice area and effective valve orifice area in the FMR group were smaller,the left ventricular end-diastolic volume(LVEDV)and left ventricular end-systolic volume(LVESV)were larger,and the left ventricular ejection fraction was smaller(all P＜0.05).One year after operation,the left ventricular end-diastolic diameter,left ventricular end-systolic diameter,LVEDV,LVESV and left atrial diameter of the two groups were lower than those before operation,the mean mitral valve pressure gradient was higher than that before operation,and the New York Heart Association heart function classification was significantly improved(all P＜0.05).The proportion of normal left ventricular shape was increased compared with baseline[DMR group:31.4％(22/70)vs 20.0％(14/70),FMR group:61.9％(13/21)vs 33.3％(7/21)],and the proportion of eccentric left ventricular hypertrophy was decreased(all P＜0.05).Conclusions For patients with moderate to severe MR of different etiologies,TEER treatment can effectively improve the degree of MR Regurgitation in the mid-term after operation,improve cardiac function,promote left ventricular reverse remodeling,and restore normal left ventricular morphology in some patients.
Keywords：Transcatheter edge-to-edge repairDegenerative mitral regurgitationFunctional mitral regurgitationLeft ventricular reverse remodeling
Publication Date：2025-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 505-510 )