Research progress on the effect of oxidative stress signal transduction pathways on fracture healing
Chen Jingren
Liu Gang
Zhu Shouquan
Wen Haicheng
Li Hongcheng
Wang Xilin
Abstract：Fractures often result in broken blood vessels and soft tissue damage,ischemia,hypoxia,and oxidative stress.Reactive oxygen species act as second messengers to activate signal transduction pathways during oxidative stress.In the presence of reactive oxygen species,Abnormal mitochondrial oxidative stress,Kelch-like epichlorohydrin related protein 1/nuclear factor E2-related factor 2/antioxidant response element signaling pathway,nuclear factor-κB signaling pathway and silent mating type information regulator 2 homologous protein 1 forkhead box transcription factor O signaling pathway can regulate the proliferation and apoptosis of osteoblasts and osteoclasts.It can affect the process of fracture healing.In recent years,the research on mitochondrial function has been on the rise,and the related research on oxidative stress-related signaling pathways and fracture healing has been progressing.Further study on the targets and mechanisms of mitochondrial oxidative stress and related signal transduction can further understand the osteogenic differentiation,osteoblast activity and osteoclast apoptosis of bone marrow mesenchymal stem cells,and provide theoretical basis for the treatment of clinical fractures.
Keywords：Fracture healingOxidative stressSignal transduction pathwaysReactive oxygen species
Publication Date：2025-03-07
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 471-475 )