Clinical study of Xiongdan Jiuxin pills combined with sacubitril/valsartan in the treatment of chronic heart failure with reduced ejection fraction
Xiang Xuan
Meng Wen
Chen Junjin
Chen Fanghong
Li Haiying
He Xueming
Abstract：Objective To investigate the clinical effect of Xiongdan Jiuxin pills combined with sacubitril/valsartan in the treatment of chronic heart failure with reduced ejection fraction.Methods A total of 120 patients with chronic heart failure with reduced ejection fraction admitted to Lianyungang Municipal Oriental Hospital Affiliated to Xuzhou Medical University from October 2020 to October 2023 were selected.According to the random number table method,they were divided into the control group and the observation group,with 60 cases in each group.All patients were given conventional treatment,the control group was given sacubitril/valsartan,and the observation group was given Xiongdan Jiuxin pills on the basis of the control group.The 6 min walk test distance,maximum exercise time,cardiac function indexes,serum indexes,and adverse reactions were compared between the two groups.Results After treatment,the 6 min walk test distance and maximum exercise time of the two groups were longer than those before treatment,and those of the observation group were longer than those of the control group(all P＜0.001).After treatment,left ventricular ejection fraction,stroke volume,cardiac output,nitric oxide and nitric oxide synthase in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group;the levels of left ventricular end-diastolic diameter,endothelin-1,laminin,hyaluronic acid and N-terminal procollagen type Ⅲ in the two groups were lower than those before treat-ment,and those in the observation group were lower than those in the control group(all P＜0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between the observation group and the control group[10.0％(6/60)vs 6.7％(4/60)](x2=0.436,P=0.509).Conclusion Xiongdan Jiuxin pills combined with sacubitril/valsartan has a significant effect on chronic heart failure with reduced ejection fraction,which can improve the exercise tolerance,cardiac function and vascular endothelial function of patients,slow down myocardial fibrosis,and has good safety.
Keywords：Chronic heart failureXiongdan Jiuxin pillsSacubitril/valsartan
Publication Date：2025-03-07
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 420-423 )