Effects of dexmedetomidine on perioperative neurocognitive disorders and inflammatory mediators in patients undergoing laparoscopic colorectal cancer surgery

Si Yukun; Cao Haitao; Liang Yanqiu; Wang Jingxu

doi:10.3760/j.issn.1673-4777.2025.03.018

Abstract：Objective To investigate the effects of dexmedetomidine on perioperative neurocognitive disorders and inflammatory mediators in patients undergoing laparoscopic colorectal cancer surgery.Methods A total of 76 patients who underwent laparoscopic colorectal cancer surgery in the Eighty-second Army Group Hospital of the Chinese People's Liberation Army from June 2021 to January 2023 were selected.According to the random number table method,the patients were divided into the control group and the observation group,with 38 cases in each group.The control group was given 0.9％sodium chloride injection by intravenous pump before anesthesia induction.The observation group was given dexmedetomidine intravenous pump before anesthesia induction.The cognitive function was compared between the two groups before anesthesia(T0),at recovery(T1),when leaving the postanesthesia care unit(T2)and 24 h after operation(T3).The levels of neurological function and inflammatory mediators in the two groups were detected.Results The Montreal Cognitive Assessment scores of the two groups at T1 and T2 were lower than those at T0,and the scores of the observation group were higher than those of the control group[(24.5±1.8)vs(22.4±2.2),(25.7±1.5)vs(23.3±2.0)](all P＜0.001).The levels of central nervous system specific protein β and neuron specific enolase at T1 and T2 in the two groups were higher than those at T0,and those in the observation group were lower than those in the control group(all P＜0.05).The levels of C-reactive protein,tumor necrosis factor-α and interleukin-6 at T,,T2 and T3 in the two groups were higher than those at T0,and those in the observation group were lower than those in the control group(all P＜0.05).Conclusion Dexmedetomidine can effectively improve cognitive function and neurological function and reduce the level of inflammatory mediators in patients undergoing laparoscopic colorectal cancer surgery.