Analysis of the correlation between serum inflammatory markers and neonatal meconium aspiration syndrome

Liu Qixing; Yang Jie

doi:10.3760/j.issn.1673-4777.2025.03.017

Abstract：Objective To investigate the correlation between serum inflammatory markers tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)and neonatal meconium aspiration syndrome(MAS).Methods Fifty-eight full-term neonates with MAS who were born in Southern Hospital of Southern Medical University and admitted to the Department of Neonatology from March 2022 to April 2023 were selected as the observation group,and 60 full-term neonates with clear amniotic fluid and normal amniotic fluid during the same period were selected as the control group.The levels of TNF-α and IL-6 were detected by enzyme-linked immunosorbent assay.According to the severity of MAS,the 58 children with MAS were divided into mild group(40 cases)and severe group(18 cases).The levels of TNF-α and IL-6 in each group were compared.The relationship between MAS and the levels of TNF-αand IL-6 was analyzed.Results The levels of IL-6 and TNF-α in the observation group were higher than those in the control group on the 1 st and 5 th day after admission(all P＜0.05).The receiver operating characteristic curve showed that the sensitivity,specificity and area under the curve of IL-6 in the diagnosis of MAS were 76.90％,76.00％and 0.825,respectively.The sensitivity,specificity and area under the curve of TNF-α in the diagnosis of MAS were 84.60％,76.00％and 0.869,respectively(all P＜0.05).The ratio of female in the severe group was higher than that in the mild group,and the levels of IL-6 and TNF-α in the severe group were higher than those in the mild group on the 1st and 5 th day after admission(all P＜0.05).The results of Logistic regression analysis showed that the levels of IL-6 and TNF-α in the 5 th day after admission were related to the occurrence of severe MAS(odds ratio=1.145,95％confidence interval:1.022-1.283,P=0.019;odds ratio=1.367,95％confidence interval:1.067-1.751,P=0.013).Conclusion The expressions of IL-6 and TNF-α in MAS,especially in severe MAS,are high,which can reflect the degree of inflammation and hypoxia,and provide impor-tant reference for the diagnosis of MAS and the evaluation of MAS.