Clinical application of nalbuphine combined with bupivacaine for caudal block in pediatric daytime laparo-scopic surgery

Li Xin; Qi Lin; Deng Hong; Qi Can; Shi Lei

doi:10.3760/j.issn.1673-4777.2025.03.016

Abstract：Objective To investigate the anesthetic effect of nalbuphine combined with bupivacaine for caudal block on pediatric daytime laparoscopic surgery and its effect on hemodynamics.Methods A total of 120 children undergoing daytime laparoscopic surgery in Hebei Children's Hospital from June 2023 to February 2024 were selected.According to the random number table method,they were divided into the composite group and the control group,with 60 cases in each group.The control group was given bupivacaine caudal block,and the composite group was given nalbuphine on the basis of the control group.The sedation,pain response index,hemo-dynamic index,sacral block effect and adverse reactions were compared between the two groups.Results At 4 and 8 h after operation,the Ramsay score and visual analogue scale score of the composite group were significantly lower than those of the control group(both P＜0.05).The levels of heart rate and mean arterial pressure at 5 min after injection and skin incision in the composite group were higher than those in the control group(all P＜0.05).The onset times of sensory and motor block in the composite group were shorter than that in the control group[(57±6)svs(79±8)s,(145±16)s vs(181±21)s],and the durations of sensory and motor block were longer than that of the control group[(177±20)min vs(137±16)min,(106±13)min vs(78±9)min](all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.378).Conclusion Nalbuphine combined with bupivacaine for caudal block in pediatric daytime laparoscopic surgery has good clinical application effect,which can effectively maintain the body's hemodynamic level,improve the sedative and analgesic effects,prolong the drug effect time,and has high safety.