The clinical application of detachable string magnetically controlled capsule endoscopy in cardiovascular disease patients with positive fecal occult blood test

Bai Guoyan; Sun Yamei; Yan Zhen; Chen Xue; Zhang Jie

doi:10.3760/j.issn.1673-4777.2025.03.013

Abstract：Objective To investigate the clinical application value of detachable string magnetically controlled capsule endoscopy(ds-MCE)in patients with a positive fecal occult blood test(FOBT)and underlying cardiovascular disease(CVD).Methods CVD patients with positive FOBT who underwent MCE at the Depart-ment of Gastroenterology,Beijing Anzhen Hospital,Capital Medical University from October 2023 to October 2024 were retrospectively enrolled.The patients who underwent ds-MCE were included in the string group,while those who underwent wireless magnetically controlled capsule endoscopy were included in the wireless group.The general information,complications,antithrombotic drug use,visualization of magnetically controlled capsule endoscopy,detected lesions,adverse reactions and adverse events related to the examination were collected.The primary outcome was the visual difference between the two groups,and the secondary outcome was the safety of ds-MCE.Results Finally,158 patients were included,including 53 cases in the string group and 105 cases in the wireless group.The visualization rates of the 4 quadrants and ≥3 quadrants for the upper,middle,and lower esophagus,as well as the dentate line,were significantly higher in the string group compared to the wireless group(all P＜0.01).In terms of gastric visualization,the visualization rate of gastric cardia in the string group was higher than that in the wireless group(P＜0.05).There was no significant difference in the detection rate of gastric and small intestinal lesions between the two groups(P＞0.05).In the string group,31(58.5％)patients did not experience any discomfort,21 cases(39.6％)reported mild pharyngeal discomfort,17 cases(32.1％)reported mild nausea,10 cases(18.9％)reported mild cough,and 1 case(1.9％)reported moderate nausea,all of which were tolerated.None of the patients had any adverse events such as capsule retention and aspiration etc.Conclusions The ds-MCE can be used to examine the esophagus,stomach and small intestine simultaneously in CVD patients with positive FOBT.It is safe and can provide accurate evidence for clinical diagnosis.