Expression of moesin and paired related homeobox protein 1 in elderly patients with non-small cell lung cancer and their correlation with the efficacy of osimertinib targeted therapy

Su Bin; Luo Cheng; Xun Xin

doi:10.3760/j.issn.1673-4777.2025.03.011

Abstract：Objective To analyze the expression of moesin and paired related homeobox protein 1(PRRX1)in elderly patients with non-small cell lung cancer(NSCLC)and their correlation with the efficacy of osimertinib targeted therapy.Methods A total of 60 elderly patients with NSCLC admitted to the 920th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from January 2021 to June 2024 were selected as the research objects.The expression levels of moesin and PRRX1 in cancer tissues and adjacent tissues were detected,and the correlation between the expression changes of moesin and PRRX1 and the efficacy of osimertinib targeted therapy was analyzed.According to the efficacy of osimertinib targeted therapy,the patients were divided into the effective treatment group(42 cases)and the ineffective treatment group(18 cases).The expression levels of moesin and PRRX1 were compared between the two groups.The predictive value of moesin and PRRX1 expressions for clinical efficacy in elderly patients with NSCLC was analyzed.Results The positive expression rates of moesin and PRRX1 in cancer tissues were 70.0％(42/60)and 83.3％(50/60),respectively.The staining area of cells was enlarged and the staining intensity was high.There were statistically significant differences in pathological type,tumor diameter,TNM stage,degree of differentiation,lymph node metastasis,capsule invasion,positive expression of moesin and PRRX1,and incidence of epidermal growth factor receptor gene mutation between the two groups(all P＜0.05).The positive rate of moesin in epidermal growth factor receptor(EGFR)gene wild-type patients was higher than that in EGFR mutant patients,and the positive expression rate of PRRX1 was lower than that of mutant patients(both P＜0.05).Spearman correlation analysis showed that the expression of moesin and PRRX1 was positively correlated with clinical efficacy(r=0.339,P＜0.001;r=0.558,P＜0.001).Multivariate Logistic regression analysis showed that pathological tissue type,maximum tumor diameter,TNM stage,degree of differentiation,lymph node metastasis,capsule invasion,mosin and PRRX1 expression were all risk factors affecting the efficacy of osimertinib targeted therapy(all P＜0.001).Receiver operating characteristic curve analysis showed that the predictive value of combined detection of moesin and PRRX1 for clinical efficacy in elderly patients with NSCLC was higher than that of moesin or PRRX1 alone.Conclusion The expressions of moesin and PRRX1 are related to the efficacy of osimertinib targeted therapy in elderly NSCLC patients,which can be predicted by combined detection,so as to provide reference for clinical treatment plan adjustment.