Analysis of risk factors and treatment outcomes of multidrug-resistant tuberculosis

Ma Qingyan; Hou Lili; Dang Ping; Kang Guannan

doi:10.3760/j.issn.1673-4777.2025.03.009

Abstract：Objective To explore the risk factors and treatment outcomes of multidrug-resistant tuberculosis.Methods A total of 160 patients with multidrug-resistant tuberculosis in Hebei Chest Hospital from January 2022 to December 2023 were selected as the drug-resistant group,and 160 patients with sensitive tuberculosis during the same period were selected as the sensitive group.The drug-resistance group was divided into observation group and control group according to the random number table method,with 80 cases in each group.The control group was treated with the regimen without bedaquiline,and the observation group was treated with the regimen containing bedaquiline,both groups received continuous treatment for 24 weeks.The general data,efficacy and adverse reactions of the two groups were compared.Multivariate Logistic regression analysis was used to analyze the risk factors of multidrug-resistant tuberculosis.Results There were significant differences in residence,marital status,anti-tuberculosis treatment history,tuberculosis cavity,tuberculosis contact history,and BCG vaccination history between the drug-resistance group and the sensitive group(all P＜0.05).The results of multivariate Logistic regression analysis showed that rural residence,married,anti-tuberculosis treatment history,tuberculosis cavity,tuberculosis contact history,and no BCG vaccination history were the risk factors for multidrug-resistant tuberculosis(all P＜0.05).There were no statistically significant differences in general data between the observation group and the control group(all P＞0.05).The total effective rate of the observation group was higher than that of the control group[86.2％(69/80)vs 70.0％(56/80)](x2=6.181,P=0.013).There was no significant differ-ence in the incidence of adverse reactions between the observation group and the control group[22.5％(18/80)vs 15.0％(12/80)](x2=1.477,P=0.224).Conclusion Rural residence,married,anti-tuberculosis treatment history,tuberculosis cavity,tuberculosis contact history and no BCG vaccination history are the risk factors for multidrug-resistant tuberculosis.Effective measures should be taken in time to avoid the occurrence of multidrug-resistant tuberculosis.Bedaquiline-containing regimen is effective and safe in the treatment of patients with multidrug-resistant tuberculosis.