Relationship between serum brain natriuretic peptide,ferritin and insulin-like growth factor 1 levels and bronchopulmonary dysplasia in premature infants

Liang Junxia; Wang Lingling; Zhu Lei; Liu Xiaojing; Xu Jinli

doi:10.3760/j.issn.1673-4777.2025.03.008

Abstract：Objective To investigate the relationship between serum brain natriuretic peptide(BNP),ferritin and insulin-like growth factor-1(IGF-1)levels and bronchopulmonary dysplasia(BPD)in preterm infants,in order to provide a scientific basis for the diagnosis of BPD.Methods A total of 80 premature infants admitted to the First Affiliated Hospital of Hebei North University from May 2021 to May 2023 were selected.According to the presence or absence of BPD within 28 days after birth,the preterm infants were divided into BPD group(38 cases)and non-BPD group(42 cases).According to the severity of BPD,the infants in the BPD group were divided into mild group(14 cases),moderate group(13 cases),and severe group(11 cases).Blood samples were collected from each subject,and their basic clinical information was collected.Serum levels of BNP,ferritin and IGF-1 were measured by enzyme-linked immunosorbent assay.The differences between BPD group and non-BPD group and between different severity subgroups of BPD were compared.Logistic regression was used to analyze the risk factors for BPD in preterm infants.Results The levels of serum BNP and ferritin in BPD group were higher than those in non-BPD group[(1 429±408)mg/L vs(137±33)mg/L,(372±120)μg/L vs(160±50)μg/L],and the level of IGF-1 was lower than that in non-BPD group[(26±8)μg/L vs(37±12)μg/L](all P＜0.05).The serum levels of BNP and ferritin in preterm infants with different severity of BPD rised with the severity of the disease,with mild group＜moderate group＜severe group;the level of IGF-1 reduced with the severity of the disease,with mild group＞moderate group＞severe group,and the differences between any two groups were statistically significant(all P＜0.05).The duration of mechanical ventilation,length of hospital stay,duration of continuous positive airway pressure,and the proportion of neonatal pneumonia and neonatal asphyxia in BPD group were higher than those in non-BPD group(all P＜0.05).Logistic regression analysis showed that serum levels of BNP and ferritin,duration of mechanical ventilation,and duration of continuous positive airway pressure were risk factors for BPD in preterm infants,while IGF-1 level was a protective factor(all P＜0.05).Conclusions The levels of serum BNP and ferritin in preterm infants with BPD are increased,and the level of IGF-1 is decreased.The three levels can be used as indicators of BPD,which are of great significance in evaluating the condition of preterm infants with BPD.